Journal: Frontiers in Pharmacology
Article Title: Comparative effectiveness of treatments for recurrent Clostridioides difficile infection: a network meta-analysis of randomized controlled trials
doi: 10.3389/fphar.2024.1430724
Figure Lengend Snippet: Main characteristics of studies included in the network meta-analysis.
Article Snippet: Van Nood-2013 , Open-label, randomized, controlled trial , Diarrhea (≥3 loose or watery stools per day for at least 2 consecutive days or ≥8 loose stools in 48 h) and a positive stool test for C. difficile toxin , 42 , Vancomycin (500 mg qid, 4 days), followed by bowel lavage with 4 L Macrogol solution (Klean-Prep) on final day of antibiotic treatment and subsequent infusion of FMT solution through a nasoduodenal tube the next day (n = 16) , Vancomycin (500 mg qid, 14 days) (n = 13), or vancomycin with bowel lavage on day 4 or 5 (n = 13) , Absence of diarrhea or persistent diarrhea explained by other causes, with three consecutive negative stool tests for C. difficile toxin , 10 weeks.
Techniques: Infection, Suspension, Enzyme Immunoassay, Polymerase Chain Reaction, Biomarker Discovery, Capsules, Neutralization, Enzyme-linked Immunosorbent Assay